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260 The SAM reduction induced by H 2 O 2 in A549 cells leads to hypomethylation of long interspersed nuclear element-1 (LINE-1)

Testing Levels: Soluble -klotho can be measured in serum using commercial ELISA kits (e.g., IBL International JP27998)

Wang YP, Sharda A, Xu SN, van Gastel N, Man CH, Choi U, Leong WZ, Li X, Scadden DT (2021) Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis

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The outcome of statistical analysis for relevant experiment and figures is included in the Source Data File

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